ea0041oc5.2 | Neuroendocrinology | ECE2016
Hoeflich Andreas
, Reyer Anja
, Schindler Nancy
, Ohde Daniela
, Wirthgen Elisa
, Brenmoehl Julia
IGFBP-2 represents a multifunctional protein with effects on growth, reproductive development, aging, and metabolism. For the expression of these diverse effects in vivo, IGFBP-2 has a number of binding sites for IGFs, integrins, and proteoglycans. In order to assess the relative contributions of these binding sites to the multiple effects of IGFBP-2, we have developed transgenic mouse models overexpressing intact or mutant IGFBP-2. Here we discuss functions of the RG...