Searchable abstracts of presentations at key conferences in endocrinology

ea0041oc5.2 | Neuroendocrinology | ECE2016

Analysis of signal transduction in mice overexpressing mutant versus intact IGFBP-2 identifies a plethora of IGFBP-2 dependent mechanisms in different tissues and suggests permissive or regulatory effects of the RGD-sequence

Hoeflich Andreas , Reyer Anja , Schindler Nancy , Ohde Daniela , Wirthgen Elisa , Brenmoehl Julia

IGFBP-2 represents a multifunctional protein with effects on growth, reproductive development, aging, and metabolism. For the expression of these diverse effects in vivo, IGFBP-2 has a number of binding sites for IGFs, integrins, and proteoglycans. In order to assess the relative contributions of these binding sites to the multiple effects of IGFBP-2, we have developed transgenic mouse models overexpressing intact or mutant IGFBP-2. Here we discuss functions of the RG...